RAF Typhoon FGR4s have conducted a mission with France's air force in a joint strike targeting an subterranean weapons facility in Syria employed by the Islamic State group (IS), as stated by the British defence ministry.
The location, located using intelligence, was assessed as storing arms and explosives, the statement said, and was situated in mountainous terrain just above the ancient city of Palmyra in Syria's central region.
"Our aircraft employed Paveway IV guided bombs to strike a number of approach shafts leading to the facility... initial indications indicate the strike was effective," the MoD said.
There was no evidence of any civilian impact in the strike late on Saturday and every plane involved made a safe return, the defence officials confirmed.
The British jets were assisted by a Voyager tanker plane.
Daesh - alternatively referred to as ISIS - established militant control over large swathes of Syria and Iraq until 2019.
"This action shows British leadership, and resolve to operate in unison with our partners, to eradicate any re-emergence of the terrorist group and their violent and radical beliefs in the region," the British Defence Secretary John Healey said.
British military aircraft have performed patrols over Syria to "prevent any attempted resurgence" of the group following its routing at the battle of Baghuz in 2019, the MoD reported.
"I must thank all the members of the UK armed forces involved in this operation for their professionalism and their courage," Healey said. "They were among thousands of British personnel on duty over Christmas and New Year. This action, to remove terrorist threats who pose a risk to our security, highlights how UK forces are prepared to act, continuously, ensuring Britain's security at home and influential overseas."
During December, the US military carried out what it described as a "massive strike" against Islamic State objectives in the country, subsequent to an assault resulted in the deaths of two US servicemembers and a civilian interpreter in Palmyra.
The U.N. estimates Daesh still maintains roughly 5-7 thousand militants in Iraq and Syria.
